Details of the Drug

General Information of Drug (ID: DMNFZC6)

Drug Name
Formic Acid
Synonyms
formate; Formic acid, ion(1-); HCO2 anion; 71-47-6; formylate; aminate; methanoate; hydrogen carboxylate; CHEMBL183491; formiate; Formate ion; a carboxyl group; Hydrogencarboxylic acid; HCOO-; AC1L18W4; GTPL4540; CTK5I5292; CHEBI:15740; DTXSID60221219; BDAGIHXWWSANSR-UHFFFAOYSA-M; BDBM50155538; STL483235
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 46.025
Topological Polar Surface Area (xlogp) -0.2
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
CH2O2
IUPAC Name
formic acid
Canonical SMILES
C(=O)O
InChI
InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)
InChIKey
BDAGIHXWWSANSR-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
284
ChEBI ID
CHEBI:30751
CAS Number
64-18-6
DrugBank ID
DB01942
TTD ID
D06EWG

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Phosphoshikimate1-carboxyvinyltransferase (Bact aroA) TTB30PF AROA_ECOLI Inhibitor [2]
Candida Mannose-6-phosphate isomerase (Candi PMI1) TT915ZD MPI_CANAL Inhibitor [2]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [2]
Delta-aminolevulinic acid dehydratase (ALAD) TTJHKYD HEM2_HUMAN Inhibitor [2]
Glutathione-dependent PGD synthase (HPGDS) TTCYE56 HPGDS_HUMAN Inhibitor [2]
Heme oxygenase 1 (HMOX1) TTI6V2A HMOX1_HUMAN Inhibitor [2]
Heparin-binding growth factor 1 (FGF1) TTMY81X FGF1_HUMAN Inhibitor [2]
Nitric-oxide synthase brain (NOS1) TTZUFI5 NOS1_HUMAN Inhibitor [2]
Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) TTBL49X HGXR_PLAFG Inhibitor [2]
Staphylococcus Peptide deformylase (Stap-coc def) TTICO5G DEF_STAAU Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Glutathione-dependent PGD synthase (HPGDS) DTT HPGDS 1.63E-05 0.34 0.71
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

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3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 ClinicalTrials.gov (NCT01748877) Efficacy, Tolerability, and Safety of NXN-462 in Patients With Post-Herpetic Neuralgia. U.S. National Institutes of Health.
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